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Previous research has linked smoking to an increased risk of Crohns disease and its complications but has also suggested that smokers are at lower risk for ulcerative colitis, Ducharme-Benard and colleagues note in the Journal of Clinical Gastroenterology

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Self-reported exposure to spousal smoke among controls in the multi-centre European casecontrol study of Boffetta et al (1998) was reported as 12.8% for men and 62.7% for women but these are values for those ever exposed, which were used in estimating the PAF in France (IARC, 2007)

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Due to the Brattleboro homozygous vasopressin-deficient rat's reduced sensitivity to several ulcerogenic stimuli compared to the rat with normal vasopressin secretion, endogenous vasopressin has been shown to operate as an aggressive factor towards the gastroduodenal mucosa [21]