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Cigarette smoking remains a leading cause of preventable disease and premature death in the United States and other countries

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Abbreviations AMI: Acute myocardial infarction CI: Confidence interval CVD: Cardiovascular disease HR: Hazard ratio ICD-10-AM: International Classification of Diseases 10th revisionAustralian Modification IHD: Ischaemic heart disease PAD: Peripheral arterial disease RR: Relative risk SAF: Smoking-attributable fraction References GBD 2016 Mortality and Causes of Death Collaborators

They are mechanistically established pathways backed by decades of epidemiologic and molecular research