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The mechanisms behind the link between tobacco smoke exposure and non-allergic rhinitis are not yet well understood, but several mechanisms likely involved are described as follows

Associations between the timing of maternal cigarette smoking and birth congenital anomalies Maternal cigarette smoking before pregnancy or during either trimester was significantly associated with six subtypes of congenital anomalies: congenital diaphragmatic hernia, gastroschisis, limb reduction defect, cleft lip with or without cleft palate, cleft palate alone, and hypospadias

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