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Social or environmental causes: Growing up in a household or family where tobacco use is considered normal or even encouraged can lead to tobacco addiction

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A study of gene expression in rat epithelium after exposure to cigarette smoke showed that smoke causes rapid induction of antioxidant stress-response genes and drug-metabolizing enzymes, such as heme oxygenase and quinone oxidoreductase, all of which had decreased expression after long-term exposure to cigarettes (Gebel et al

Tobacco kills up to 50% of its users

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