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Despite producing fewer toxins, they still pose health risks associated with tobacco use, including nicotine addiction and other long-term effects

Furthermore, given that the COPD itself is regarded as a risk factor in selecting the candidate for lung cancer screening [17, 18], it would be of interest to estimate the degree of lung cancer risk reduction in patients with COPD by the amount of smoking reduction

Land echoed this point, noting that few studies of patients with cancer have collected data on participants smoking status over time

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