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London: NICE, 2007, 2011

It also highlights the broader oral health risks associated with smoking, such as periodontal disease, tooth loss, oral cancer, and dry mouth

13 Contributing Factors Marketing Early marketing strategies used by companies producing and selling e-cigarettes as they were first introduced in the United States in 2006 were largely adult-focused, in that e-cigarettes were marketed as a safer alternative to conventional cigarettes and an easier way to quit smoking than other nicotine-cessation devices

Research: To understand the connection between smoking and health, pack years are frequently employed in medical research investigations

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