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Once there, smoke-expanded pools of alveolar macrophages are paradoxically less effective: phagocytosis, autophagy, antigen presentation, and production of key cytokines such as tumor necrosis factor- (TNF-), interleukin-12 (IL-12), and interferon- (IFN-) are all attenuated, while a shift toward anti-inflammatory M2 phenotypes and smoke-induced metabolic exhaustion enable intracellular survival of the pathogen (Leemans et al., 2005

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For example, the Food and Drug Administration (FDA) has assembled a list of 93 hazardous or potentially hazardous constituents (HPHC) of tobacco products, some of which have to be reported annually to FDA [5]

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FDA regulates the manufacture, import, packaging, labeling, advertising, promotion, sale, and distribution of pipe tobacco, including components and parts such as pipes,* under the FD&C Act and its implementing regulations