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Indeed, cotinine was ineffective even at concentrations exceeding 1 M (0.1-1 mM), and addition of cotinine to NT (1M nicotine + 1 mM cotinine) did not significantly affect histamine release or the NT-induced inhibition of LTC 4 (data not shown)

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Another aspect to consider is that many parts of the world only have access to limited brands, so their only cruelty-free options are owned by large corporations