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Exposure to tobacco smoke in utero has been associated with abnormalities in lung development and small airway dysfunction in school-age children, manifested by reductions in forced expiratory volume in 1 second (FEV1) and forced expiratory flow 2575 percent (FEF2575 percent) (den Dekker et al., 2015

Elife 3:e03496 Wang C, Gu W, Zhang Y, Ji Y, Wen Y, Xu X (2017a) Nicotine promotes cervical carcinoma cell line HeLa migration and invasion by activating PI3k/Akt/NF-kB pathway in vitro

Performing preventive services: a bright futures handbook [Available from: Futures Documents/Anticipatory Guidance.pdf

It's all rather engrossing, for about an hour

Furthermore, nicotine has been shown to negate NO-induced vasodilation and cause cerebral hypoperfusion by degrading the NO, possibly resulting from oxidative stress (Toda and Toda 2010)