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Several other patents for nicotine devices were filed throughout the 1990s, but it would again be over 20 years before the modern e-cigarette was born

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Across all participants, greater decreases in cigarette use correlated with greater phase 1 systolic BP responses and greater decreases in systolic BP during phase 2

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Clinicians need to be aware of this pattern as it might be an initial indication of a connective tissue disorder that needs a specialist referral