Azide-Hexanoyl-Val-Cit-PAB(m-PEG8)-Exatecan cit Product Name Thalidomide-C6-Br Synonyms Thalidomide-4'-C6-Br

Product Name Thalidomide-C6-Br Synonyms Thalidomide-4'-C6-Br CAS Number n/a Related CAS Molecular Formula C19H21BrN2O4 Molecular Weight 421

NBD-TM is a thiomorpholine-based fluorogenic probe for HOCl

Product Name DBCO-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8) Synonyms CAS Number Related CAS Molecular Formula C68H101N9O21 Molecular Weight 1380

Product Name Thalidomide-5'-piperidine-C1-piperazine HCl Synonyms CAS Number n/a Related CAS Molecular Formula C23H31Cl2N5O4 Molecular Weight 512

28 SMILES: CC(=O)OC1=C(Cl)C=C2C(OC3=CC(OC(C)=O)=C(Cl)C=C3C22OC(=O)C3=CC(=CC=C23)C(O)=O)=C1

Azide-Hexanoyl-Val-Cit-PAB(m-PEG8)-Exatecan cit Product Name Thalidomide-C6-Br Synonyms Thalidomide-4'-C6-BrSOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC