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This provides a mechanistic link between environmental factors (e.g., Western diet) and the control of inflammation at the level of innate immune cells

10.1016/j.pbi.2008.03.008 78 RhoadesM

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Oxidative stress changes in different stages of carcinogenesis During the initiation stage of cancer, which is characterized by increasing levels of oxidative stress, genetic alterations facilitate cellular survival (adaptation to oxidative stress) via the activation of antioxidant transcription factors and/or the increase in NADPH production, which is required for fueling the antioxidant machinery (Iqbal et al