Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG4)-PNP DBCO Iberdomide promotes degradation of Aiolos

Iberdomide promotes degradation of Aiolos and Ikaros proteins

Product Name Thalidomide-C3-PEG4-OH Synonyms Thalidomide-4'-C3-PEG4-OH CAS Number n/a Related CAS Molecular Formula C24H32N2O9 Molecular Weight 492

Sulforhodamine 101 alkyne (Texes Red alkyne) is an excellent azide-reactive fluorescent reagent for labeling azide-containing biological molecules through click chemistry

677 SMILES: [O-]C(=O)C1=CC=C(C=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)C(=O)NCC#C

5 Purity (HPLC) >= 95% Solubility DMSO

Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG4)-PNP DBCO Iberdomide promotes degradation of AiolosSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating leaving group, enabling efficient and selective conjugation of the payload