Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG4)-MMAE AHPC 96 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])C(C)(C)C)C=C1 Purity (HPLC)

96 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name BG-Biotin Synonyms SNAP-Biotin CAS Number n/a Related CAS Molecular Formula C23H28N8O3S Molecular Weight 496

Product Name Pomalidomide-acetamido-O-PEG2-C2-Cl Synonyms Pomalidomide-4'-acetamido-O-PEG2-C2-Cl CAS Number n/a Related CAS Molecular Formula C21H24ClN3O8 Molecular Weight 481

Product Name Lenalidomide-PEG2-OH Synonyms Lenalidomide-4'-PEG2-OH CAS Number n/a Related CAS Molecular Formula C17H21N3O5 Molecular Weight 347

and cell death

Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG4)-MMAE AHPC 96 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])C(C)(C)C)C=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to