Mal-Propionyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-Exatecan maleimide and drug development

and drug development

SiR-Azide is a far-red fluorescent probe containg azide moiety for click chemustry apploications

resulting in cytochrome c release and caspase-dependent cell death

BG-Cy3 is a SNAP-tag substrate with Cyanine3 dye

HaloTag SiR Ligand

Mal-Propionyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-Exatecan maleimide and drug developmentSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Propionyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is