Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG8)-PNP snap The cell-impermeant 5

The cell-impermeant 5

Product Name HB007 Synonyms CAS Number 2387821-46-5 Related CAS Molecular Formula C15H9ClN4S2 Molecular Weight 344

11 Purity (HPLC) >= 95% Solubility DMSO

which binds to DCAF1 with a Kd by SPR and IC50 by TR-FRET of <50 nM

563 SMILES OCCOCCOCCOCCOCCOCC#CC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG8)-PNP snap The cell-impermeant 5SOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating