Propargyl-Gly(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan Size:10mg 421 SMILES [N-]=[N+]=NCCOCCOCCNC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC)
Propargyl-Gly(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan Size:10mg 421 SMILES [N-]=[N+]=NCCOCCOCCNC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Propargyl Gly(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The propargyl functional group is widely employed in click chemistry to undergo selective cycloaddition with azides. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The
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