DBCO-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8) Thalidomide 583 SMILES OCCOCCOCCOCCOCCOCCNC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)

583 SMILES OCCOCCOCCOCCOCCOCCNC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

39 Purity (HPLC) >= 95% Solubility DMSO

26 SMILES CC1(N)CCN(CC1)C1=CN=C(C(N)=N1)C1=C(Cl)C(Cl)=CC=C1 Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO

Product Name Pomalidomide-acetamido-O-PEG3-C2-Cl Synonyms Pomalidomide-4'-acetamido-O-PEG3-C2-Cl CAS Number n/a Related CAS Molecular Formula C23H28ClN3O9 Molecular Weight 525

Product Name DOTA-tris(t-Bu)ester-C6-acid Synonyms CAS Number n/a Related CAS Molecular Formula C35H65N5O9 Molecular Weight 699

DBCO-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8) Thalidomide 583 SMILES OCCOCCOCCOCCOCCOCCNC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a DBCO Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further