DBCO-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-Exatecan dbco-lys-m-PEG4 NCCCOC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95%

NCCCOC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

NRX-1933 acts as molecular glue in cells to promote the ubiquitylation and subsequent degradation of mutantbeta-catenin by the 26S proteasome

92 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCCOCCO)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

TMR C2 maleimides have higher labeling efficiency

12 SMILES: [2H]C([2H])([2H])OC1=CC=C(C=C1)B1OC(C)(C)C(C)(C)O1 Isotopic Enrichment: 98 atom % D Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

DBCO-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-Exatecan dbco-lys-m-PEG4 NCCCOC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95%SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a DBCO Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further