Azide-Dap(m-PEG4)-Val-Cit-OH biotin 866 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCO)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC)

866 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCO)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

438 SMILES CC(C)(C)C1=CC=CC(OC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=C1 Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO

328 SMILES OC(=O)CCNC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Nature 2014

CDg18 is the first M2 macrophage selective fluorescent probe

Azide-Dap(m-PEG4)-Val-Cit-OH biotin 866 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCO)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Azide Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The azide functional group is widely utilized in bioconjugation via click chemistry to enable efficient and selective attachment of biomolecules. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine