DBCO-Propionyl-Val-Cit-PAB(m-PEG8)-Exatecan building block Product Name Pomalidomide-5'-C1-acid Synonyms CAS

Product Name Pomalidomide-5'-C1-acid Synonyms CAS Number 2412056-27-8 Related CAS Molecular Formula C15H13N3O6 Molecular Weight 331

265 SMILES NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

438 SMILES CC(C)(C)C1=CC=CC(OC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)=C1 Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO

S)-AHPC-CO-C5-OH Synonyms CAS Number n/a Related CAS Molecular Formula C28H40N4O5S Molecular Weight 544

Product Name Trametinib Synonyms CAS Number 871700-17-3 Related CAS Molecular Formula C26H23FIN5O4 Molecular Weight 615

DBCO-Propionyl-Val-Cit-PAB(m-PEG8)-Exatecan building block Product Name Pomalidomide-5'-C1-acid Synonyms CASSOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC