Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-MMAE protac ligand 127 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCOCCOCCOCCOCCOCC#C)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC)

127 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCOCCOCCOCCOCCOCC#C)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

SNAP-tag reacts with covalently with benzylguanine (BG)or chloropyrimidine (CP) derivatives

1021/acschembio

Product Name Mal-Lys(m-PEG4)-Val-Cit-PAB Synonyms CAS Number Related CAS Molecular Formula C38H59N7O12 Molecular Weight 805

exhibited longer fluorescence lifetimes than its non-sulfonated counterparts

Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-MMAE protac ligand 127 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCOCCOCCOCCOCCOCC#C)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to