MC-Val-Cit-PAB(m-PEG8)-Exatecan m-peg4 Product Name Phthalimidinoglutarimide-5'-C4-OH Synonyms CAS

Product Name Phthalimidinoglutarimide-5'-C4-OH Synonyms CAS Number 2736497-81-5  Related CAS Molecular Formula C17H20N2O4 Molecular Weight 316

Fmoc-Val-Cit-PAB-PNP is a cleavable ADC linker used in antibody–drug conjugate (ADC) development

CA-PEG4-amide-PEG4-Bition is a Biotin-HaloTag ligand that enables rapid labeling of Halo-tagged proteins and their efficient isolation via streptavidin pull-down

5-FAM azide is an excellent alkyne-reactive fluorescent reagent for labeling azide-containing biological molecules through click chemitry

1038/nature13527

MC-Val-Cit-PAB(m-PEG8)-Exatecan m-peg4 Product Name Phthalimidinoglutarimide-5'-C4-OH Synonyms CASSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures,