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Neuroscience and Biobehavioral Reviews, 149 , 105168

The combined effect of GIP and GLP-1 receptor activation is synergistic, producing results greater than what either pathway achieves alone

10.1139/H07-147 180 SajjadianF.RoshangarL.HemmatiA.NoriM.Soleimani-RadS.Soleimani-RadJ

For instance, oxidative stress disrupts redox-sensitive organelles, including the endoplasmic reticulum (ER) [9], leading to the accumulation of misfolded proteins, which triggers ER stress and impairs protein folding, modification, and transport [10]