Mal-Propionyl-PEG8-Val-Cit-PAB(m-PEG4)-Exatecan deuterium-labeled-ether 338 SMILES OCCOCCOC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)

338 SMILES OCCOCCOC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma

S)-AHPC-acetamido-O-PEG4-C1-acid Synonyms CAS Number 2172820-13-0 Related CAS Molecular Formula C34H50N4O11S Molecular Weight 722

Product Name tert-butyl 2-[4-(2-aminoethyl)piperazin-1-yl]acetate Synonyms CAS Number n/a Related CAS Molecular Formula C12H25N3O2 Molecular Weight 243

Product Name BG-SulfoCy3 Synonyms SNAP-SulfoCy3 CAS Number Related CAS Molecular Formula C43H48N8O8S2 Molecular Weight 869

Mal-Propionyl-PEG8-Val-Cit-PAB(m-PEG4)-Exatecan deuterium-labeled-ether 338 SMILES OCCOCCOC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG8 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I