DOTA-tris(t-Bu)ester-PEG5-C2-propanamido-maleimide hoechst NRX-1532 acts as molecular glue

NRX-1532 acts as molecular glue in cells to promote the ubiquitylation and subsequent degradation of mutantbeta-catenin by the 26S proteasome

NCCCNC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Thalidomide-O-acetamido-PEG2-C2-azide Synonyms Thalidomide-4'-O-acetamido-PEG2-C2-azide CAS Number n/a Related CAS Molecular Formula C21H24N6O8 Molecular Weight 488

Product Name Lenalidomide-5'-CO-C3-acid Synonyms CAS Number 2759015-47-7 Related CAS Molecular Formula C18H19N3O6 Molecular Weight 373

forming an irreversible covalent bond

DOTA-tris(t-Bu)ester-PEG5-C2-propanamido-maleimide hoechst NRX-1532 acts as molecular glueDOTA bifucational chelator containing a thiol reactive maleimide group, a PEG linker, and the macrocyclic chelator DOTA ( 1,4,7,10 tetraazacyclododecane 1,4,7,10 tetraacetic acid). It can be used in many different diagnostic and therapeutic applications, such as MRI contrast agents, PET and SPECT imaging agents, and radiotherapeutic agents. Product Name DOTA tris(t Bu)ester PEG5 C2 propanamido maleimide Synonyms CAS Number n a Related CAS Molecular