DBCO-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-PNP Size:50mg 744 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCC(=O)N2CC3=C(C=CC=C3)C#CC3=C2C=CC=C3)CCN(CC(O)=O)CC1 Purity (HPLC)

744 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCC(=O)N2CC3=C(C=CC=C3)C#CC3=C2C=CC=C3)CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

025 Purity (HPLC) >= 95% Solubility DMSO

146 SMILES BrC1=CC=C2CN(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Azide-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan Synonyms CAS Number Related CAS Molecular Formula C66H90FN13O20 Molecular Weight 1404

Excitation maximum = 649 nm

DBCO-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-PNP Size:50mg 744 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCC(=O)N2CC3=C(C=CC=C3)C#CC3=C2C=CC=C3)CCN(CC(O)=O)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a DBCO Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further