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Abbreviations BC: breast cancer TAM: tumor-associated macrophages CCL5: C-C motif chemokine ligand 5 CCR1/3: chemokine receptor 1/3 VCAM-1: vascular cell adhesion molecule 1 E-cig: E-cigarettes CS: cigarette smoking MMPs: matrix metalloproteinases VEGF: vascular endothelial growth factor TNF: tumor necrosis factor EVC: E-cigarette vapor condesate Declarations Acknowledgement None

With ever-increasing disposal costs, land application of wood ash will probably be the disposal choice in the coming century as it results in savings for the industry, an opportunity for agriculture and conservation of our resources