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Lin et al., 2024

At doses between 0.2 to 1.2mg/daily, hGH therapy has been reported to [18]: Restore lean mass (up to 5% increase from pretreatment levels) Reduce abdominal fat (up to 10% reduction in adiposity from pretreatment levels) Slow osteoporosis development Reduce LDL by up to 16% from pretreatment levels Improve quality of life However, hGH appears to have a considerably smaller impact on individuals with normal pituitary function

Future interventions that selectively modulate neutrophil activation, ROS generation, or NET formationsuch as PAD4 inhibitors, ROS scavengers, DNase-based therapies, or blockade of neutrophilplatelet interactionshold promise to shift PCOS management from symptomatic hormone modulation toward precision immuno-metabolic therapy