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Limited drug penetration and nonspecific distribution not only diminish the therapeutic effectiveness but also increase the risk of off-target effects

Interestingly, analysis of The Cancer Genome Atlas (TCGA) revealed that higher levels of mRNAs encoding the circadian clock repressor CRY2 were associated with improved survival in patients with glioma, thus supporting the hypothesis that the use of CRY-stabilizing compounds might be a promising strategy for glioblastoma therapy in humans 145

In mammalian cells, it was shown that the HIF-prolyl hydroxylases were represented by a series of isoforms bearing a conserved 2-histidine-1-carboxylate-iron coordination motif at the catalytic site

No study has reported extension of mammalian life with NAC-alone and, on the contrary, supplementing NAC-alone in C

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