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Variations in the MTHFR gene can affect how the body metabolises B vitamins, including B12

The corresponding pharmacokinetic parameters are listed as follows: T max = 0.167 h, C max = 155 11.8 ng Eq./ml, AUC 0t = 4945 417 h ng Eq./ml, AUC 0 = 12956 2074 hng Eq./ml, average residence time (MRT 0-t ) of plasma total radioactivity = 33.2 1.03 h, and t 1/2 = 102 h (Table 9)

It is not an approved medicine and competitive athletes should note that it appears on anti-doping prohibited lists

(The complex pharmacological mechanism of natural products is shown in Figure 2)

Animal studies suggest it works through specific cellular signaling pathways (FAK-paxillin and ERK1/2) to ramp up this repair process