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Oxidative stress causes damage to DNA, RNA, proteins, mitochondrial membranes, and lipids and contributes to the functional decline of mitochondria, cells, tissues, and eventually organs such as the brain

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Exp Ther Med 23:363 Ferrario M, Cambiaghi A, Brunelli L, Giordano S, Caironi P, Guatteri L, Raimondi F, Gattinoni L, Latini R, Masson S, Ristagno G, Pastorelli R (2016) Mortality prediction in patients with severe septic shock: a pilot study using a target metabolomics approach

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