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Symptoms may start to improve within 2 weeks of being diagnosed and treated, but improvement may take up to 3 months

[DOI] [PMC free article] [PubMed] [Google Scholar] 185.Piehl-Aulin K., Jones I., Lindvall B., Magnuson A., Abdel-Halim S.M

Enoksson et al

The DMMB assay 35 provided precise measures of GAG release which complemented the semi-quantitative grading of GAG loss used in the cross-sectional comparison of herniated and degenerated discs

My only hesitation in accepting the hypothesis that obesity is a downstream effect of hypothalamic inflammation lies in the fact that, in metabolically healthy individuals, a normally functioning digestive system, a non-steatotic liver, nutrient-sensitive pancreas and intestine, insulin-sensitive adipose tissue, should mitigate, at least to some extent (though not completely), the negative effects of an unhealthy diet, until their compensatory capacity fails