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Among them, 6HFh8-aFGF and 6HFh8-VEGF165 obtained high respective yields of 9.7 and 3.4 g/L in a 5-L batch supplement fermentation, with a purity of more than 99%

Establishment of CIA model All animal experiments were authorized by the Institutional Animal Ethics Review Board of the Shanghai Ninth Peoples Hospital, Shanghai Jiao Tong University School of Medicine (Approve No

doi: 10.1016/j.prostaglandins.2019.106338 174 KarpishehVJoshiNZekiyAOBeyzaiBHojjat-FarsangiMNamdarAet al

Notably, the gene knockout or inhibition of SIRT4 reverses these changes, therefore mitigating renal fibrosis induced by UUO/IRI/FA treatment (Yang et al., 2024)

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