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Knockdown of Nrf2 reverses these effects, confirming that WFA exerts neuroprotection via Nrf2-dependent suppression of ferroptosis

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The expression profiles showed that the GRA group was characterized by predominant expression of immune-related genes ( ULBP family, GZMM , GZMK , HCST , CCL22 ), whereas the SUP group exhibited elevated expression of growth factor receptors ( FGFR2 ), signaling molecules ( SEMA3E , GPRC5A ), and selenoproteins ( SELENOW )

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