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The blood glucose levels in streptozotocin-treated mice were titrated to a non-toxic range with daily subcutaneously injections of long-acting insulin glargine (Fisher Scientific, NC0767732)

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Licznerski P, Park H-A, Rolyan H, Chen R, Mnatsakanyan N, Miranda P, et al

Kim SH, Kang KA, Zhang R, Piao MJ, Ko DO, Wang ZH, Chae SW, Kang SS, Lee KH, Kang HK, Kang HW, Hyun JW (2008) Protective effect of esculetin against oxidative stress-induced cell damage via scavenging reactive oxygen species

Although the patients were randomized to treatment groups, the patients/parents and healthcare providers (except the pediatric neurologist who evaluated EEG recordings) were not blinded to the treatment in a particular child, which could be a source of bias