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This is provided because of the past reliance on chelator enhanced elimination as a primary therapy The role of selenium supplementation in mercury poisoning therapy including: restoration of selenoprotein activity, pro-demeythlating action of selenium, sequestering of mercury via Hg:Se complexes, redistribution of Hg inside organisms under the influence of Se, the inhibitory effects of Se on actions of Hg How the different forms of mercury are effected by use of chelation elimination and selenium supplementation Synergy or conflicts between use of selenium, acetylcysteine and the thiol chelators unithiol and succimer Mechanisms of action and mercury elimination by thiol chelators and acetylcysteine Thiol-based chelators have been a mainstay of therapy for mercury toxicity for decades [Citation3, Citation4]

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Burg D, Filippov DV, Hermanns R, van der Marel GA, van Boom JH, Mulder GJ

Soltan-SharifiMSMojtahedzadehMNajafiAKhajaviMRRouiniMRMoradiMet alImprovement by N-acetylcysteine of acute respiratory distress syndrome through increasing intracellular glutathione, and extracellular thiol molecules and anti-oxidant power: evidence for underlying toxicological mechanisms