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doi: 10.1038/s43018-020-00160-x 66 GaulDAMezencevRLongTQJonesCMBenignoBBGrayAet al

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However, investigation of the effect of UA on such models is limited by the profound differences between humans and e.g., rodents in UA metabolism, primarily due to the loss in humans of a functional uricase

In contrast, GSTP1 promotes ER stress-induced apoptosis in liver cancer by glutathionylating SERCA, thereby inhibiting pro-survival MAPK8 signaling 50