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High doses may cause temporary headaches due to increased NAD+ turnover and mitochondrial activity

Additional studies have investigated its influence on vascular endothelial growth factor (VEGF) and transforming growth factor-beta (TGF-?), signaling molecules that play important roles in hair follicle growth, vascularization, and cycling

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These nerve-related changes can occur even without anemia being present, which means standard blood counts alone may not catch a developing deficiency

NAD+ declines naturally with age, contributing to reduced cellular function, decreased energy production, and impaired DNA repair