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Potential mechanism of emphysema: a1-Proteinase inhibitor recovered from lungs of cigarette smokers contains oxidized methionine and has decreased elastase inhibitory capacity (oxidant/obstructive lung Disease/leukocyte)

The figure also highlights the potential of anti-cancer nutraceuticals- natural compounds such as curcumin, resveratrol, EGCG, and sulforaphane, in targeting these hallmarks