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23 The benefits of exercise in cardiovascular health can also be related to exercise-induced physiological cardiac hypertrophy, structural and functional vascular remodeling, as well as cardiac metabolic adaptations in mitochondrial function and glucose/lipid metabolism

When the damage surpasses the cells repair capacity, apoptotic pathways are activated, involving the expression of p53 and Bcl2 Associated X Protein (BAX, part of the Bcl-2 family proteins), the cytochrome c release, and the activation of caspase-3, -7 and -9, leading to apoptosis [2,19,24,30,31]

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