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Prologue This review re-examines the under-appreciated molecular manifestation of Friedreichs ataxia (FRDA) associated with oxidative modification of the cytoskeleton

Said modified FX polypeptides provided herein include those having at least a 2 fold increase, 5 times, 10 times, 20 times, 30 times, 40 times, and generally at least 50 times, such as at least 100 times or more, of increased dependence on the cofactor, when in active form, compared to the polypeptide of FXa unmodified that does not contain the one or more modifications

When the concept of ferroptosis was initially proposed, researchers identified key features of ferroptosis in HT-1080 cells using H2DCFDA and C11-BODIPY fluorescent probes (38)