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Computational Models for Predicting the Binding Affinities of Ligands for the Wild-Type Androgen Receptor and a Mutated Variant Associated with Human Prostate Cancer.Chem

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The bioavailability difference between the two routes compounds the distinction: topical application creates a localized skin depot, while injection delivers the peptide systemically at concentrations impossible to achieve through the skin barrier

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doi:10.1016/j.pop.2018.02.004 7 Hochberg MC, Thomas J, Thomas DJ, Mead L, Levine DM, Klag MJ