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In age-related neurological disorders such as AD, the catalytic activity of pyruvate dehydrogenase is suppressed, leading to decreased acetyl-CoA production and impaired TCA cycle energy metabolism (Sang et al

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Of the 28 metazoan PRX6 sequences, we found that 19 encode the full PLA 2 catalytic triad, H S D, and nine encode the full G X S X G with no substitutions (Purple residues and purple box, respectively