glutathione reductase reaction mechanism Schematic diagram showing the conversion of (GSH) from the Glutathione reductase - Wikipedia

Farge T, Saland E, de Toni F, Aroua N, Hosseini M, Perry R, Bosc C, Sugita M, Stuani L, Fraisse M, Scotland S, Larrue C, Boutzen H, Fliu V, Nicolau-Travers M-L, Cassant-Sourdy S, Broin N, David M, Serhan N, Sarry A, Tavitian S, Kaoma T, Vallar L, Iacovoni J, Linares LK, Montersino C, Castellano R, Griessinger E, Collette Y, Duchamp O, Barreira Y, Hirsch P, Palama T, Gales L, Delhommeau F, Garmy-Susini BH, Portais J-C, Vergez F, Selak M, Danet-Desnoyers G, Carroll M, Rcher C, Sarry J-E

European Association for the Study of Diabetes (EASD)

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Both in vitro and in vivo assay demonstrated that METTL14 induced N6 -methyladenosine (m 6 A) modification at 5UTR of SLC7A11 mRNA, which promotes SLC7A11 mRNA stability and upregulates its expression by inhibiting the deadenylation process, enhancing ferroptosis resistance (Fan et al., 2021

[PubMed 3416746] 1187