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After gently removing residual fecal contents with cold phosphate-buffered saline, the colon was placed on a flat surface without stretching, and its length was measured using a calibrated ruler

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It will be of great clinical importance to reveal which cancer genotypes correspond to cell cycle arrest, or even senescence and apoptosis, in response to inhibitor treatment, and which bypass routes may be used by cancer cells to acquire resistance to CDK4/6-specific inhibitors

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