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doi: 10.1016/j.tplants.2026.03.003

3 Barriers to clinical application and physicochemical challenges 3.1 Physicochemical barriers Curcumin, a polyphenolic compound with the chemical formula CHO, exhibits pronounced hydrophobicity (log P 3.2) and low aqueous solubility, which severely restricts its dissolution and bioavailability in physiological environments [24]

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As the essential substrate for thyroglobulin iodination, iodine availability dictates systemic T4 and T3 production (141, 142)