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These results suggest that inhibiting depalmitoylation of ATG2 can mimic the consequences observed upon loss of ATG2, leading to impaired autophagosome formation (Velikkakath et al, 2012)

Figure 1 illustrates how diet interfaces with the multifactorial pathophysiology of AD, highlighting anatomical vulnerability, molecular cascades, and potential dietary interventions

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Since the inhibitory effect of phytate on zinc absorption is concentration-dependent, the molar phytate: zinc-ratio of the diet (Table 1) is applied to estimate zinc bioavailability [49] and was shown to be more important than the phytate content of the product itself [171,172]