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Furthermore, HIF-1 inhibits ferritin-heavy polypeptide 1 (FTH1) through miR-210-3p, accumulating Fe 2+ , which subsequently generates OH through the Fenton reaction ( The interaction between oxidative stress and epigenetic regulation is manifested by the upregulation of ROS, which increases the expression of DNA methyltransferase 3B (DNMT3B), leading to elevated methylation levels of the SRY-related HMG-box gene 9 (Sox9) promoter and inhibiting the synthesis of aggrecan

The same 10 mg vial targeting 5 mg/mL needs 2.0 mL, while targeting 2.5 mg/mL requires 4.0 mL

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et Zucc.), Ligustri Lucidi Fructus (LLF, the fruit of Ligustrum lucidum Ait.), Herba Plantaginis (HP, the dried whole grass of Plantago asiatica L.), and Nidus Vespae (NV, the honeycomb of Polistes olivaceus (De Geer), Polistes Japonicus Saussure, or Parapolybiavaria Fabricius) (224)