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The cosmetically or pharmaceutically (therapeutically) effective amount of the compounds of the invention which should be administered, as well as their dosage, will depend on numerous factors, including age, state of the patient, the nature or severity of the condition, disorder or disease to be treated and/or cared for, the route and frequency of administration and of the particular nature of the compounds to be used

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Such protein-level analysis is crucial for understanding how genetic variations in LMNA affect the proteins function and structure, directly linking to the phenotypic diversity seen in laminopathies

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